C/EBPβ mediates tumour-induced ubiquitin ligase atrogin1/MAFbx upregulation and muscle wasting
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چکیده
منابع مشابه
C/EBPβ mediates tumour-induced ubiquitin ligase atrogin1/MAFbx upregulation and muscle wasting.
Upregulation of ubiquitin ligase atrogin1/MAFbx and muscle wasting are hallmarks of cancer cachexia; however, the underlying mechanism is undefined. Here, we describe a novel signalling pathway through which Lewis lung carcinoma (LLC) induces atrogin1/MAFbx upregulation and muscle wasting. C2C12 myotubes treated with LLC-conditioned medium (LCM) rapidly activates p38 MAPK and AKT while inactiva...
متن کاملC/EBPβ mediates tumor-induced ubiquitin ligase atrogin1/MAFbx upregulation and muscle wasting
As you will see, all three referees recognise the interest in your work, but all also raise a significant number of concerns that would need to be addressed before we could consider publication. Most notable amongst these are the comments of referee 3 regarding the need for larger group sizes in the in vivo experiments. Extending the study accordingly would be an essential pre-requisite for pot...
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Statins inhibit HMG-CoA reductase, a key enzyme in cholesterol synthesis, and are widely used to treat hypercholesterolemia. These drugs can lead to a number of side effects in muscle, including muscle fiber breakdown; however, the mechanisms of muscle injury by statins are poorly understood. We report that lovastatin induced the expression of atrogin-1, a key gene involved in skeletal muscle a...
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ژورنال
عنوان ژورنال: The EMBO Journal
سال: 2011
ISSN: 0261-4189
DOI: 10.1038/emboj.2011.292